PUBLICATIONS (n= 67; 01/2021)
SCIENTIFIC RESEARCH PAPERS-PEER REVIEWED (n=49)
* Denotes Trainees or Supervised Staff
1. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F. The effect of a Chromogranin A-derived peptide (CgA4-16) in the writhing nociceptive response induced by acetic acid in rats. Life Sci. 2004; Aug 27, 75 (15): 1787-99. https://www.ncbi.nlm.nih.gov/pubmed/15302224
2. Ghia JE, Crenner F, Rohr S, Meyer C, Metz-Boutigue MH, Aunis D, Angel F. A role for Chromogranin A (4–16), a vasostatin-derived peptide, on human colonic motility. An in-vitro study. Regul. Pept. 2004; Sep 15, 121 (1–3): 31-9. https://www.ncbi.nlm.nih.gov/pubmed/15256271
3. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F. Effects of a Chromogranin-derived peptide (CgA 47–66) in the writhing nociceptive response induced by acetic acid in rats. Regul. Pept. 2004; Jul 15, 119 (3): 199–207. https://www.ncbi.nlm.nih.gov/pubmed/15120481
4. Ghia JE, Pradaud I*, Crenner F, Metz-Boutigue MH, Aunis D, Angel F. Effect of acetic acid or trypsin application on rat colonic motility in vitro and modulation by two synthetic fragments of Chromogranin A. Regul. Pept. 2005; Jan 15, 124 (1–3): 27–35. https://www.ncbi.nlm.nih.gov/pubmed/15544838
5. Ghia JE, Blennerhassett P*, Verdu E, Ondiveeran KH, Collins SM. The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006; Oct, 131 (4): 1122-1130
https://www.ncbi.nlm.nih.gov/pubmed/17030182
6. Verma-Gandhu M, Verdu E, Bercik P, Blennerhassett P*, Al-Mutawaly N, Ghia JE, Collins SM. Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse. Gut 2007; Mar, 56 (3): 358-64 https://www.ncbi.nlm.nih.gov/pubmed/17018864
7. Ghia JE, Blennerhassett P*, Collins SM. Vagal integrity and experimental colitis. Am. J. Physiol. 2007; Sep, 293 (3): G500-507
https://www.ncbi.nlm.nih.gov/pubmed/17585014
8. Ghia JE, Blennerhassett P*, El-Sharkawy RT and Collins SM. The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Am. J. Physiol. 2007; Oct, 293 (4): G711-718
https://www.ncbi.nlm.nih.gov/pubmed/17673544
9. Motomura Y, Ghia JE, El-Sharkawy RT, McLaughlin J, Grencis RK, Collins M, Khan WI. Enterochromaffin cells and 5-HT response to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 2008; Apr, 57 (4): 475-81 https://www.ncbi.nlm.nih.gov/pubmed/18198200
10. Ghia JE, Galeazzi F, Ford DC, Hogaboam CM, Vallance BA and Collins SM. Role of M-CSF dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am. J. Physiol. 2008; Mar, 294 (3): G770-777
https://www.ncbi.nlm.nih.gov/pubmed/18202111
11. Ghia JE, Blennerhassett P*, Collins SM. Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a model of mouse depression J. Clin. Invest. 2008; June, 118 (6): 2209-2218
https://www.ncbi.nlm.nih.gov/pubmed/18451995
12. Ghia JE, Blennerhassett P*, Deng Y*, Verdu E, Khan WI and Collins SM. Reactivation of inflammatory bowel disease in a mouse model of depression. Gastroenterology 2009; June, 136 (7): 2280-2288
https://www.ncbi.nlm.nih.gov/pubmed/19272381
13. Ghia JE, Li N*, Wang H*, Collins M, Deng Y*, El-Sharkawy RT, Cote F, Mallet J and Khan WI. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 2009; Nov, 137 (5): 1649–1660 https://www.ncbi.nlm.nih.gov/pubmed/19706294
14. Hasnain SZ, Wang H*, Ghia JE, Haq N, Deng Y*, Grencis RK, Velcich A, Thornton
DJ and Khan WI. Mucin Gene Deficiency in Mice Impairs Host Resistance to Enteric Parasitic Infection. Gastroenterology 2010; May, 138 (5): 1763–1771 https://www.ncbi.nlm.nih.gov/pubmed/20138044
15. Ghia JE, Blennerhassett P*, Khan WI, Collins SM. The adoptive transfer of susceptibility to colitis by macrophages from mice with depression-like behavior. Inflammatory Bowel Disease 2011; Jul 17 (7): 1474–1489 https://www.ncbi.nlm.nih.gov/pubmed/21246669
16. Ghia JE, Li N*, Wang H*, Cote F, Suehiro Y, Mallet J & Khan WI. Serotonin activates dendritic cell function in the context of gut inflammation. Am. J. Pathol. 2011; Feb, 178 (2): 662–671 *Equal contribution
https://www.ncbi.nlm.nih.gov/pubmed/21281798
17. Rahimian R, Dehpour AR, Fakhfouri G, Khorramizadeh MR, Ghia JE, Seyedabadi M, Caldarelli A, Mousavizadeh K, Forouzandeh M, Mehr SE. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011; Oct, 1417:1–8. https://www.ncbi.nlm.nih.gov/pubmed/21914553
18. Thanasupawat T, Hammje K, Adham I, Ghia JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T, Hombach-Klonisch S. INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumors. Oncol. Rep. 2013, Jan 29 (1):149-54
https://www.ncbi.nlm.nih.gov/pubmed/23128569
19. Kim JJ*, Bridle BW, Ghia JE, Wang H, Manocha MM, Rengasamy P, Shajib MS*, Wan Y, Hedlund PB, Khan WI. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J. Immunol. 2013, May, 190 (9): 4795-804 https://www.ncbi.nlm.nih.gov/pubmed/23554310
20. Park AJ*, Collins J, Blennerhassett P*, Ghia JE, Verdu EF, Bercik P, Collins SM. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastrol. Motil. 2013, Sept, 25 (9) : 733-e575 https://www.ncbi.nlm.nih.gov/pubmed/23773726
21. Shajib MS*, Wang H*, Kim JJ*, Sunjic I, Ghia JE, Denou E, Collins M, Denburg JA, Khan WI. Interleukin 13 and serotonin: linking the immune and endocrine systems in intestinal inflammation, PLoS One 2013, Aug 28; 8 (8), e72774 https://www.ncbi.nlm.nih.gov/pubmed/24015275
22. Rahimian R, Fakhfouri G, Samadi P, Mehr SE, Ghia JE, Genazzani AA, Dehpour AR, Mousavizadeh K, Lim D. Tropisetron Attenuates Amyloid-Beta-Induced Inflammatory and Apoptotic Responses and cognitive disturbance in Rats. Eur. J. Clin. Invest. 2013, Oct, 43 (10) : 1039–1051 https://www.ncbi.nlm.nih.gov/pubmed/23937291
23. JI H*, Rabbi MF*, Labis B*, Pavlov VA, Tracey KJ, Ghia JE. Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis. Mucosal. Immunol. 2014, Mar 7 (2): 335–347 *Equal contribution https://www.ncbi.nlm.nih.gov/pubmed/23881354
24. Nagy JI, Urena-Ramirez V*, Ghia JE. Functional deviations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons. FEBS Lett. 2014, Apr, 588 (8): 1480–1490 https://www.ncbi.nlm.nih.gov/pubmed/24548563
25. Rabbi MF*, Labis B*, Metz-Boutigue MH, Bernstein CN, Ghia JE. Catestatin decreases macrophage function in two mouse models of experimental colitis. Biochem. Pharmacol. 2014, Jun, 89 (3): 386-398 https://www.ncbi.nlm.nih.gov/pubmed/24637240
26. Munyaka P*, Rabbi MF*, Pavlov VA, Tracey KJ, Khafipour E, Ghia JE. Central muscarinic cholinergic activation alters dendritic cells function in experimental colitis. PLoS 1 Oct 8, 2014; 9 (10): e109272. doi : 10.1371/journal.pone.0109272. eCollection 2014
https://www.ncbi.nlm.nih.gov/pubmed/25295619
27. Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford RJ, Collins A, Blumer R, Fullerton M, Kim J, Ghia JE, Hamza S, Morrison K, Dyck J, Schertzer J, Khan W, Yabut J, Steinberg G. Inhibiting peripheral serotonin reduces obesity, non-alcoholic fatty liver disease and insulin resistance by promoting brown adipose tissue thermogenesis. Nat. Med. Feb 2015; 21 (2): 166-72
https://www.ncbi.nlm.nih.gov/pubmed/25485911
28. Munyaka PM*, Eissa N*, Bernstein CN, Khafipour E, Ghia JE. Antepartum antibiotic treatment increases offspring’s susceptibility to experimental colitis: a role of the gut microbiota. PLoS One Nov 2015; 10 (11): e0142536 https://www.ncbi.nlm.nih.gov/pubmed/26605545
29. Heydarpour P, Rahimian R, Fakhfouri G, Khoshkish S, Salehi-Sadaghiani M, Abbasi A, Wang HX*, Ahmad Reza Dehpour AR, Ghia JE. Behavioral despair associated with a mouse model of Crohn’s disease: Role of nitric oxide pathway. Prog Neuropsychopharmacol. Biol. Psychiatry Jan 2016; 64: 141-141 https://www.ncbi.nlm.nih.gov/pubmed/26268932
30. Bernstein CN, Banerjee A, Targownik LE, Singh H, Ghia JE, Burchill C, Chateau D,
Roos LL. Caesarian section is not a risk factor for the development of IBD: A population based analysis. Clin. Gastroenterol. Hepatol. Jan 2016; 14 (1): 50–57
https://www.ncbi.nlm.nih.gov/pubmed/26264640
31. Munyaka PM*, Sepehri S, Ghia JE and Khafipour E. Carrageenan gum and adheren invasive Escherichia coli in a piglet model of inflammatory bowel disease: impact on intestinal mucosa-associated microbiota. Front. Microbiol. Apr 5, 2016; 7; 462 https://www.ncbi.nlm.nih.gov/pubmed/27092122
32. Munyaka PM*, Rabbi MF*, Khafipour E, Ghia JE. Acute dextran sulfate sodium (DSS)-induced colitis promotes gut microbial dysbiosis in mice. J. Basic Microbiol. 2016 Sep; 56 (9): 986-998
https://www.ncbi.nlm.nih.gov/pubmed/27112251
33. Eissa N*, Hussein H*, Rabbi MF*, Khafipour A*, Munyaka PM*, Bernstein CN, Ghia JE. Stability of Reference Genes for Messenger RNA Quantification by Real-Time PCR in Mouse Dextran Sodium Sulfate Experimental Colitis. PLoS 1 May 31, 2016; 11 (5): e0156289
https://www.ncbi.nlm.nih.gov/pubmed/27244258
34. Bernstein CN, Burchill C, Targownik L, Singh H, Ghia JE, Roos LL. Maternal antibiotic that would warrant antibiotic use antepartum or peripartum are not a risk factor for the development of IBD: A population-based analysis. Inflamm. Bowel Dis. Apr 23, 2017 (4): 635–640
https://www.ncbi.nlm.nih.gov/pubmed/28195851
35. Rabbi MF*, Munyaka PM*, Eissa N*, Khafipour E, Ghia JE. Human Catestatin induces gut microbiota dysbiosis in mouse. Front. Microbiol. Jan 17, 2017; 7: 2551 https://www.ncbi.nlm.nih.gov/pubmed/28144234
36. Eissa N*, Kermarrec L*, Hussein H*, Bernstein CN, Ghia JE. Appropriateness of reference genes for normalizing messenger RNA in mouse 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis using quantitative real time PCR. Sci. Rep. Feb 2017; 7 : 42427
https://www.ncbi.nlm.nih.gov/pubmed/28186172
37. Rabbi MF*, Eissa N*, Munyaka PM*, Kermarrec L*, Elgazzar O*, Khafipour E, Bernstein CN, Ghia JE. Reactivation of intestinal inflammation is suppressed by Catestatin in a murine model of colitis via M1 macrophages and not the gut microbiota. Frontiers in Immunology, section Inflammation, 2017, 8:985. ecollection 2017
https://www.ncbi.nlm.nih.gov/pubmed/28871257
38. Eissa N*, Hussein H*, Kermarrec L*, Elgazzar O*, Metz-Boutigue MH, Bernstein CN, Ghia JE. Chromofungin ameliorates the progression of colitis through regulation of Alternative Activated Macrophages and Improvement of Epithelial Barrier Functions Original article, Frontiers Immunology, section Inflammation, 2017, 8:1131. ecollection 2017
https://www.ncbi.nlm.nih.gov/pubmed/28951733
39. Eissa N*, Hussein H*, Kermarrec L*, Grover J*, Metz-Boutigue MH, Bernstein CN, Ghia JE. Chromofungin (CHR: CHGA47-66) is down regulated in persons with active ulcerative colitis and suppresses pro-inflammatory macrophage function through the inhibition of NF-kB signaling. Original article, Biochemical & Pharmacology, 2017, 145:102–113
https://www.ncbi.nlm.nih.gov/pubmed/28827109
40. Eissa N*, Kermarrec L*, Hussein H*, Ali AY, Marshall A, Metz-Boutigue MH, Hendy GF, Bernstein CN, Ghia JE. Chromogranin-A regulates macrophage function and the apoptotic pathway in patients with active ulcerative colitis. Original article, Journal of Molecular Medicine, Feb 2018; 96 (2):183–192 https://www.ncbi.nlm.nih.gov/pubmed/29274006
41. Ali A, Wu X, Eissa N, Hou S, Ghia JE, Murooka T, Banerji V, Johnston J, Lin F, Gibson S, Marshall A distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration, Leukemia, 2018 sept; 32(9):1958-1969 https://www.ncbi.nlm.nih.gov/pubmed/29479062
42. Eissa N*, Hussein N*, Messgna R*, Bonin S*, Hendy GN, Metz-Boutigue MH, Bernstein CN, GHIA JE.Catestatin Regulates Epithelial Cell Dynamics to Improve Intestinal Inflammation, Vaccines, 2018 Sep 20; 6(4) pii: E67 https://www.ncbi.nlm.nih.gov/pubmed/30241336
-2019-
43. Know E, Wang H, Denou E, Ghia JE, Rossi L, Fontes M E, Bernier SP, Shajib S, Banskote S, Collins SM, Surette MG, Khan WI. Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis, Cellular and Molecular Gastroenterology and Hepatology, 2019, 7 (4):709-728
https://www.ncbi.nlm.nih.gov/pubmed/30716420
44. Kermarrec L*, Eissa N*, Wang HX*, Kapoor K*, Diarra A*, Soussi-Gounni A, Bernstein CN, Ghia JE.Semaphorin-3E attenuates intestinal inflammation through the regulation of the communication between splenic CD 11C+ and CD4+ CD25- T-cells, British Journal of Pharmacology, 2019 May; 176(9):1235-1250 https://www.ncbi.nlm.nih.gov/pubmed/30736100
45. Yang XT, Zhang WR, Tian ZC, Wang K, Ding WJ, Liu Y, Wang CX, Leng HX, Peng M, Zhao WF, Li JY, Yang L, Zhang XY, Wu L, Wang JH, Fernandez A, Si TM, Fu LH, Ghia JE, Dong HQ, WangYP, Wang HX. Depressive severity associated with cesarean section in young depressed individuals. Chin Med J (Engl). 2019 Jul 10. doi: 10.1097/CM9.0000000000000326.
https://www.ncbi.nlm.nih.gov/pubmed/31306226
46. Grover J, Chhuneja P, Midha V, Ghia JE, Deka D, Mukhopadhyay CS, Sood N, Mahajan R, Singh A, Verma R, Bansal E, Sood A. Variable Immunogenic Potential of Wheat: Prospective for Selection of Innocuous Varieties for Celiac Disease Patients via in vitro Approach. Front Immunol. 2019 Feb 04; 10:84
https://www.ncbi.nlm.nih.gov/pubmed/30804930
47. Eissa N*, Heyam Hussein*, Diarra A*, Omar Elgazzar*, Soussi-Gounni A, Bernstein CN, Ghia JE.Semaphorin-3E regulates apoptosis in the intestinal epithelium during the development of colitis, Biochem. Pharmacol., 2019 May, 166:264-273
https://www.ncbi.nlm.nih.gov/pubmed/31170375
48. Khafipour A*, Eissa N*, Peris M. Munyaka*, Rabbi MF*, Kunal Kapoor*, Kermarrec L*, Khafipour E, Bernstein C, Ghia JE. Denosumab regulates microbiota composition and cytokine in dinitrobenzene sulfonic acid (DNBS)-experimental colitis Front Immunol. 2020 June, 11:1405
https://pubmed.ncbi.nlm.nih.gov/32670246/
49. Eissa N*, Hussein H*, Tshikudi D M*, Hendy G, Bernstein C, Ghia JE. Interdependence Between Chromogranin-A, Alternatively Activated Macrophages, Tight Junction Proteins and the Epithelial Functions. A Human and in-Vivo/in-Vitro Descriptive Study. Original article, International Journal of Medical Science, Nov 2020, 21(21): E7976
https://pubmed.ncbi.nlm.nih.gov/33121008/
EDUCATION PAPERS-PEER REVIEWED
1. Ghia JE & Amara F. Practical strategies for effective small group learning in case-based tutorials: solutions to the challenges. Med. Sci. Edu. Jour., 2017, 27:767-778 https://link.springer.com/article/10.1007/s40670-017-0463-8
2. Ghia JE, Gaulin S, Ghia L, Garancher L, Flamand. Informing children citizens efficiently to better engage them in the fight against COVID-19. Original viewpoint, PLOS Neglected Tropical Diseases, Nov 2020, 14(11):e008828
https://pubmed.ncbi.nlm.nih.gov/33147222/
RESEARCH BOOK CHAPTER
1. Eissa N*, Kermarrec L*, Ghia JE. Neuroimmune mechanisms of cerebellar development and its developmental disorders: Bidirectional link between the immune system and nervous system.Development of the Cerebellum - From Molecular Aspects to Diseases, Elsevier, July 2017ISBN: 978-3-319-59748-5 (Print) 978-3-319-59749-2 (Online) https://link.springer.com/chapter/10.1007/978-3-319-59749-2_13/fulltext.html
2. Eissa N*, Hussein H* & Ghia JE. Book Chapter: Gene expression analysis of M1 and M2 polarized macrophages Methods in Molecular Biology: Immunometabolism – Springer. October 020. In press
https://pubmed.ncbi.nlm.nih.gov/32808223/
REVIEW PAPERS-PEER REVIEWED (n=11)
1. Khan WI and Ghia JE Gut hormones: Emerging Role in Immune Activation and Inflammation. Clin. Exp. Immunol. Jul 2010; 161 (1): 19–27 https://www.ncbi.nlm.nih.gov/pubmed/20408856
2. Fakhfouri G, Rahimian R, Ghia JE, Khan WI, Dehpour AR. Impact of 5HT3 receptor antagonists on peripheral and central disease. Drug Discov. Today Jul 2012; 17 (13–14): 741-7
3. Khafipour E & Ghia JE. Mode of delivery and inflammatory disorders. J. Immunol. Clin. Res. September 2013, 1–1004
4. Gharedaghi MH, Seyedabadi M, Ghia JE, Dehpour AR, Rahimian R. The role of different serotonin receptor subtypes in seizure susceptibility. Exp. Brain. Res. Feb 2014; 232 (2): 347-67
https://www.ncbi.nlm.nih.gov/pubmed/24232860
5. Munyaka P*, Khafipour E & Ghia JE. External influence of early childhood establishment of gut microbiota and subsequent health implications. Front. Pediatr. Oct 2014; 2:109
https://www.ncbi.nlm.nih.gov/pubmed/25346925
6. Fakhfouri G, Mousavizadeh K, Mehr SE, Dehpour AR, Zirak MR, Ghia JE, Rahimian R. From Chemotherapy-induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 receptor Antagonists. Mol. Neurobiol. Dec 2015; 52 (3): 1670–1679
https://www.ncbi.nlm.nih.gov/pubmed/25377794
7. Eissa N* & Ghia JE. Immunomodulatory effect of ghrelin in the intestinal mucosa. Commissioned review, Neurogastroenterol. Motil., 2015 27 (11): 1519–1527
https://www.ncbi.nlm.nih.gov/pubmed/26503163
8. Beyder A#, de Lartigue G#, Ghia JE#, Hoffman JM#. XIVth Little Brain Big Brain:
next-generation enteric neuroscience. Nat Rev Gastroenterol Hepatol. 14 (3): 135–136, Jan 5, 2017. #Co-last author (Alphabetical order)
https://www.ncbi.nlm.nih.gov/pubmed/28053339
9. Seyedabadi M, Rahimian R*, Ghia JE. The role of alpha7 nicotinic acetylcholine receptors in inflammatory bowel disease: involvement of different cellular pathways. Expert Opin Ther Targets. Feb 2018; 22 (2):161–176.
https://www.ncbi.nlm.nih.gov/pubmed/29298542
10. Eissa N*, Hussein H*, Hendy GN, Bernstein CN, Ghia JE. Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation.Biochemical Pharmacology, April 2018; 152:315–326.
https://www.ncbi.nlm.nih.gov/pubmed/29656116
11. Banskota S, Ghia JE, Khan WI. Serotonin in the gut: Blessing or a curse. Biochimie Jun 2019; 161:56-64
https://www.ncbi.nlm.nih.gov/pubmed/29909048
EDUCATION – MEDICAL STUDENT TEXT BOOK – CHAPTER
1. Poitras P, Groleau V & Ghia JE. Chapitre l’estomac, L’appareil digestif 3 ed, 2019, Les Presses de l’Université de Montréal, 2020
https://www.pum.umontreal.ca/catalogue/lappareil_digestif_3e_ed
SCIENTIFIC RESEARCH PAPERS-PEER REVIEWED (n=49)
* Denotes Trainees or Supervised Staff
1. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F. The effect of a Chromogranin A-derived peptide (CgA4-16) in the writhing nociceptive response induced by acetic acid in rats. Life Sci. 2004; Aug 27, 75 (15): 1787-99. https://www.ncbi.nlm.nih.gov/pubmed/15302224
2. Ghia JE, Crenner F, Rohr S, Meyer C, Metz-Boutigue MH, Aunis D, Angel F. A role for Chromogranin A (4–16), a vasostatin-derived peptide, on human colonic motility. An in-vitro study. Regul. Pept. 2004; Sep 15, 121 (1–3): 31-9. https://www.ncbi.nlm.nih.gov/pubmed/15256271
3. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F. Effects of a Chromogranin-derived peptide (CgA 47–66) in the writhing nociceptive response induced by acetic acid in rats. Regul. Pept. 2004; Jul 15, 119 (3): 199–207. https://www.ncbi.nlm.nih.gov/pubmed/15120481
4. Ghia JE, Pradaud I*, Crenner F, Metz-Boutigue MH, Aunis D, Angel F. Effect of acetic acid or trypsin application on rat colonic motility in vitro and modulation by two synthetic fragments of Chromogranin A. Regul. Pept. 2005; Jan 15, 124 (1–3): 27–35. https://www.ncbi.nlm.nih.gov/pubmed/15544838
5. Ghia JE, Blennerhassett P*, Verdu E, Ondiveeran KH, Collins SM. The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006; Oct, 131 (4): 1122-1130
https://www.ncbi.nlm.nih.gov/pubmed/17030182
6. Verma-Gandhu M, Verdu E, Bercik P, Blennerhassett P*, Al-Mutawaly N, Ghia JE, Collins SM. Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse. Gut 2007; Mar, 56 (3): 358-64 https://www.ncbi.nlm.nih.gov/pubmed/17018864
7. Ghia JE, Blennerhassett P*, Collins SM. Vagal integrity and experimental colitis. Am. J. Physiol. 2007; Sep, 293 (3): G500-507
https://www.ncbi.nlm.nih.gov/pubmed/17585014
8. Ghia JE, Blennerhassett P*, El-Sharkawy RT and Collins SM. The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Am. J. Physiol. 2007; Oct, 293 (4): G711-718
https://www.ncbi.nlm.nih.gov/pubmed/17673544
9. Motomura Y, Ghia JE, El-Sharkawy RT, McLaughlin J, Grencis RK, Collins M, Khan WI. Enterochromaffin cells and 5-HT response to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 2008; Apr, 57 (4): 475-81 https://www.ncbi.nlm.nih.gov/pubmed/18198200
10. Ghia JE, Galeazzi F, Ford DC, Hogaboam CM, Vallance BA and Collins SM. Role of M-CSF dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am. J. Physiol. 2008; Mar, 294 (3): G770-777
https://www.ncbi.nlm.nih.gov/pubmed/18202111
11. Ghia JE, Blennerhassett P*, Collins SM. Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a model of mouse depression J. Clin. Invest. 2008; June, 118 (6): 2209-2218
https://www.ncbi.nlm.nih.gov/pubmed/18451995
12. Ghia JE, Blennerhassett P*, Deng Y*, Verdu E, Khan WI and Collins SM. Reactivation of inflammatory bowel disease in a mouse model of depression. Gastroenterology 2009; June, 136 (7): 2280-2288
https://www.ncbi.nlm.nih.gov/pubmed/19272381
13. Ghia JE, Li N*, Wang H*, Collins M, Deng Y*, El-Sharkawy RT, Cote F, Mallet J and Khan WI. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 2009; Nov, 137 (5): 1649–1660 https://www.ncbi.nlm.nih.gov/pubmed/19706294
14. Hasnain SZ, Wang H*, Ghia JE, Haq N, Deng Y*, Grencis RK, Velcich A, Thornton
DJ and Khan WI. Mucin Gene Deficiency in Mice Impairs Host Resistance to Enteric Parasitic Infection. Gastroenterology 2010; May, 138 (5): 1763–1771 https://www.ncbi.nlm.nih.gov/pubmed/20138044
15. Ghia JE, Blennerhassett P*, Khan WI, Collins SM. The adoptive transfer of susceptibility to colitis by macrophages from mice with depression-like behavior. Inflammatory Bowel Disease 2011; Jul 17 (7): 1474–1489 https://www.ncbi.nlm.nih.gov/pubmed/21246669
16. Ghia JE, Li N*, Wang H*, Cote F, Suehiro Y, Mallet J & Khan WI. Serotonin activates dendritic cell function in the context of gut inflammation. Am. J. Pathol. 2011; Feb, 178 (2): 662–671 *Equal contribution
https://www.ncbi.nlm.nih.gov/pubmed/21281798
17. Rahimian R, Dehpour AR, Fakhfouri G, Khorramizadeh MR, Ghia JE, Seyedabadi M, Caldarelli A, Mousavizadeh K, Forouzandeh M, Mehr SE. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011; Oct, 1417:1–8. https://www.ncbi.nlm.nih.gov/pubmed/21914553
18. Thanasupawat T, Hammje K, Adham I, Ghia JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T, Hombach-Klonisch S. INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumors. Oncol. Rep. 2013, Jan 29 (1):149-54
https://www.ncbi.nlm.nih.gov/pubmed/23128569
19. Kim JJ*, Bridle BW, Ghia JE, Wang H, Manocha MM, Rengasamy P, Shajib MS*, Wan Y, Hedlund PB, Khan WI. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J. Immunol. 2013, May, 190 (9): 4795-804 https://www.ncbi.nlm.nih.gov/pubmed/23554310
20. Park AJ*, Collins J, Blennerhassett P*, Ghia JE, Verdu EF, Bercik P, Collins SM. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastrol. Motil. 2013, Sept, 25 (9) : 733-e575 https://www.ncbi.nlm.nih.gov/pubmed/23773726
21. Shajib MS*, Wang H*, Kim JJ*, Sunjic I, Ghia JE, Denou E, Collins M, Denburg JA, Khan WI. Interleukin 13 and serotonin: linking the immune and endocrine systems in intestinal inflammation, PLoS One 2013, Aug 28; 8 (8), e72774 https://www.ncbi.nlm.nih.gov/pubmed/24015275
22. Rahimian R, Fakhfouri G, Samadi P, Mehr SE, Ghia JE, Genazzani AA, Dehpour AR, Mousavizadeh K, Lim D. Tropisetron Attenuates Amyloid-Beta-Induced Inflammatory and Apoptotic Responses and cognitive disturbance in Rats. Eur. J. Clin. Invest. 2013, Oct, 43 (10) : 1039–1051 https://www.ncbi.nlm.nih.gov/pubmed/23937291
23. JI H*, Rabbi MF*, Labis B*, Pavlov VA, Tracey KJ, Ghia JE. Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis. Mucosal. Immunol. 2014, Mar 7 (2): 335–347 *Equal contribution https://www.ncbi.nlm.nih.gov/pubmed/23881354
24. Nagy JI, Urena-Ramirez V*, Ghia JE. Functional deviations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons. FEBS Lett. 2014, Apr, 588 (8): 1480–1490 https://www.ncbi.nlm.nih.gov/pubmed/24548563
25. Rabbi MF*, Labis B*, Metz-Boutigue MH, Bernstein CN, Ghia JE. Catestatin decreases macrophage function in two mouse models of experimental colitis. Biochem. Pharmacol. 2014, Jun, 89 (3): 386-398 https://www.ncbi.nlm.nih.gov/pubmed/24637240
26. Munyaka P*, Rabbi MF*, Pavlov VA, Tracey KJ, Khafipour E, Ghia JE. Central muscarinic cholinergic activation alters dendritic cells function in experimental colitis. PLoS 1 Oct 8, 2014; 9 (10): e109272. doi : 10.1371/journal.pone.0109272. eCollection 2014
https://www.ncbi.nlm.nih.gov/pubmed/25295619
27. Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford RJ, Collins A, Blumer R, Fullerton M, Kim J, Ghia JE, Hamza S, Morrison K, Dyck J, Schertzer J, Khan W, Yabut J, Steinberg G. Inhibiting peripheral serotonin reduces obesity, non-alcoholic fatty liver disease and insulin resistance by promoting brown adipose tissue thermogenesis. Nat. Med. Feb 2015; 21 (2): 166-72
https://www.ncbi.nlm.nih.gov/pubmed/25485911
28. Munyaka PM*, Eissa N*, Bernstein CN, Khafipour E, Ghia JE. Antepartum antibiotic treatment increases offspring’s susceptibility to experimental colitis: a role of the gut microbiota. PLoS One Nov 2015; 10 (11): e0142536 https://www.ncbi.nlm.nih.gov/pubmed/26605545
29. Heydarpour P, Rahimian R, Fakhfouri G, Khoshkish S, Salehi-Sadaghiani M, Abbasi A, Wang HX*, Ahmad Reza Dehpour AR, Ghia JE. Behavioral despair associated with a mouse model of Crohn’s disease: Role of nitric oxide pathway. Prog Neuropsychopharmacol. Biol. Psychiatry Jan 2016; 64: 141-141 https://www.ncbi.nlm.nih.gov/pubmed/26268932
30. Bernstein CN, Banerjee A, Targownik LE, Singh H, Ghia JE, Burchill C, Chateau D,
Roos LL. Caesarian section is not a risk factor for the development of IBD: A population based analysis. Clin. Gastroenterol. Hepatol. Jan 2016; 14 (1): 50–57
https://www.ncbi.nlm.nih.gov/pubmed/26264640
31. Munyaka PM*, Sepehri S, Ghia JE and Khafipour E. Carrageenan gum and adheren invasive Escherichia coli in a piglet model of inflammatory bowel disease: impact on intestinal mucosa-associated microbiota. Front. Microbiol. Apr 5, 2016; 7; 462 https://www.ncbi.nlm.nih.gov/pubmed/27092122
32. Munyaka PM*, Rabbi MF*, Khafipour E, Ghia JE. Acute dextran sulfate sodium (DSS)-induced colitis promotes gut microbial dysbiosis in mice. J. Basic Microbiol. 2016 Sep; 56 (9): 986-998
https://www.ncbi.nlm.nih.gov/pubmed/27112251
33. Eissa N*, Hussein H*, Rabbi MF*, Khafipour A*, Munyaka PM*, Bernstein CN, Ghia JE. Stability of Reference Genes for Messenger RNA Quantification by Real-Time PCR in Mouse Dextran Sodium Sulfate Experimental Colitis. PLoS 1 May 31, 2016; 11 (5): e0156289
https://www.ncbi.nlm.nih.gov/pubmed/27244258
34. Bernstein CN, Burchill C, Targownik L, Singh H, Ghia JE, Roos LL. Maternal antibiotic that would warrant antibiotic use antepartum or peripartum are not a risk factor for the development of IBD: A population-based analysis. Inflamm. Bowel Dis. Apr 23, 2017 (4): 635–640
https://www.ncbi.nlm.nih.gov/pubmed/28195851
35. Rabbi MF*, Munyaka PM*, Eissa N*, Khafipour E, Ghia JE. Human Catestatin induces gut microbiota dysbiosis in mouse. Front. Microbiol. Jan 17, 2017; 7: 2551 https://www.ncbi.nlm.nih.gov/pubmed/28144234
36. Eissa N*, Kermarrec L*, Hussein H*, Bernstein CN, Ghia JE. Appropriateness of reference genes for normalizing messenger RNA in mouse 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis using quantitative real time PCR. Sci. Rep. Feb 2017; 7 : 42427
https://www.ncbi.nlm.nih.gov/pubmed/28186172
37. Rabbi MF*, Eissa N*, Munyaka PM*, Kermarrec L*, Elgazzar O*, Khafipour E, Bernstein CN, Ghia JE. Reactivation of intestinal inflammation is suppressed by Catestatin in a murine model of colitis via M1 macrophages and not the gut microbiota. Frontiers in Immunology, section Inflammation, 2017, 8:985. ecollection 2017
https://www.ncbi.nlm.nih.gov/pubmed/28871257
38. Eissa N*, Hussein H*, Kermarrec L*, Elgazzar O*, Metz-Boutigue MH, Bernstein CN, Ghia JE. Chromofungin ameliorates the progression of colitis through regulation of Alternative Activated Macrophages and Improvement of Epithelial Barrier Functions Original article, Frontiers Immunology, section Inflammation, 2017, 8:1131. ecollection 2017
https://www.ncbi.nlm.nih.gov/pubmed/28951733
39. Eissa N*, Hussein H*, Kermarrec L*, Grover J*, Metz-Boutigue MH, Bernstein CN, Ghia JE. Chromofungin (CHR: CHGA47-66) is down regulated in persons with active ulcerative colitis and suppresses pro-inflammatory macrophage function through the inhibition of NF-kB signaling. Original article, Biochemical & Pharmacology, 2017, 145:102–113
https://www.ncbi.nlm.nih.gov/pubmed/28827109
40. Eissa N*, Kermarrec L*, Hussein H*, Ali AY, Marshall A, Metz-Boutigue MH, Hendy GF, Bernstein CN, Ghia JE. Chromogranin-A regulates macrophage function and the apoptotic pathway in patients with active ulcerative colitis. Original article, Journal of Molecular Medicine, Feb 2018; 96 (2):183–192 https://www.ncbi.nlm.nih.gov/pubmed/29274006
41. Ali A, Wu X, Eissa N, Hou S, Ghia JE, Murooka T, Banerji V, Johnston J, Lin F, Gibson S, Marshall A distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration, Leukemia, 2018 sept; 32(9):1958-1969 https://www.ncbi.nlm.nih.gov/pubmed/29479062
42. Eissa N*, Hussein N*, Messgna R*, Bonin S*, Hendy GN, Metz-Boutigue MH, Bernstein CN, GHIA JE.Catestatin Regulates Epithelial Cell Dynamics to Improve Intestinal Inflammation, Vaccines, 2018 Sep 20; 6(4) pii: E67 https://www.ncbi.nlm.nih.gov/pubmed/30241336
-2019-
43. Know E, Wang H, Denou E, Ghia JE, Rossi L, Fontes M E, Bernier SP, Shajib S, Banskote S, Collins SM, Surette MG, Khan WI. Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis, Cellular and Molecular Gastroenterology and Hepatology, 2019, 7 (4):709-728
https://www.ncbi.nlm.nih.gov/pubmed/30716420
44. Kermarrec L*, Eissa N*, Wang HX*, Kapoor K*, Diarra A*, Soussi-Gounni A, Bernstein CN, Ghia JE.Semaphorin-3E attenuates intestinal inflammation through the regulation of the communication between splenic CD 11C+ and CD4+ CD25- T-cells, British Journal of Pharmacology, 2019 May; 176(9):1235-1250 https://www.ncbi.nlm.nih.gov/pubmed/30736100
45. Yang XT, Zhang WR, Tian ZC, Wang K, Ding WJ, Liu Y, Wang CX, Leng HX, Peng M, Zhao WF, Li JY, Yang L, Zhang XY, Wu L, Wang JH, Fernandez A, Si TM, Fu LH, Ghia JE, Dong HQ, WangYP, Wang HX. Depressive severity associated with cesarean section in young depressed individuals. Chin Med J (Engl). 2019 Jul 10. doi: 10.1097/CM9.0000000000000326.
https://www.ncbi.nlm.nih.gov/pubmed/31306226
46. Grover J, Chhuneja P, Midha V, Ghia JE, Deka D, Mukhopadhyay CS, Sood N, Mahajan R, Singh A, Verma R, Bansal E, Sood A. Variable Immunogenic Potential of Wheat: Prospective for Selection of Innocuous Varieties for Celiac Disease Patients via in vitro Approach. Front Immunol. 2019 Feb 04; 10:84
https://www.ncbi.nlm.nih.gov/pubmed/30804930
47. Eissa N*, Heyam Hussein*, Diarra A*, Omar Elgazzar*, Soussi-Gounni A, Bernstein CN, Ghia JE.Semaphorin-3E regulates apoptosis in the intestinal epithelium during the development of colitis, Biochem. Pharmacol., 2019 May, 166:264-273
https://www.ncbi.nlm.nih.gov/pubmed/31170375
48. Khafipour A*, Eissa N*, Peris M. Munyaka*, Rabbi MF*, Kunal Kapoor*, Kermarrec L*, Khafipour E, Bernstein C, Ghia JE. Denosumab regulates microbiota composition and cytokine in dinitrobenzene sulfonic acid (DNBS)-experimental colitis Front Immunol. 2020 June, 11:1405
https://pubmed.ncbi.nlm.nih.gov/32670246/
49. Eissa N*, Hussein H*, Tshikudi D M*, Hendy G, Bernstein C, Ghia JE. Interdependence Between Chromogranin-A, Alternatively Activated Macrophages, Tight Junction Proteins and the Epithelial Functions. A Human and in-Vivo/in-Vitro Descriptive Study. Original article, International Journal of Medical Science, Nov 2020, 21(21): E7976
https://pubmed.ncbi.nlm.nih.gov/33121008/
EDUCATION PAPERS-PEER REVIEWED
1. Ghia JE & Amara F. Practical strategies for effective small group learning in case-based tutorials: solutions to the challenges. Med. Sci. Edu. Jour., 2017, 27:767-778 https://link.springer.com/article/10.1007/s40670-017-0463-8
2. Ghia JE, Gaulin S, Ghia L, Garancher L, Flamand. Informing children citizens efficiently to better engage them in the fight against COVID-19. Original viewpoint, PLOS Neglected Tropical Diseases, Nov 2020, 14(11):e008828
https://pubmed.ncbi.nlm.nih.gov/33147222/
RESEARCH BOOK CHAPTER
1. Eissa N*, Kermarrec L*, Ghia JE. Neuroimmune mechanisms of cerebellar development and its developmental disorders: Bidirectional link between the immune system and nervous system.Development of the Cerebellum - From Molecular Aspects to Diseases, Elsevier, July 2017ISBN: 978-3-319-59748-5 (Print) 978-3-319-59749-2 (Online) https://link.springer.com/chapter/10.1007/978-3-319-59749-2_13/fulltext.html
2. Eissa N*, Hussein H* & Ghia JE. Book Chapter: Gene expression analysis of M1 and M2 polarized macrophages Methods in Molecular Biology: Immunometabolism – Springer. October 020. In press
https://pubmed.ncbi.nlm.nih.gov/32808223/
REVIEW PAPERS-PEER REVIEWED (n=11)
1. Khan WI and Ghia JE Gut hormones: Emerging Role in Immune Activation and Inflammation. Clin. Exp. Immunol. Jul 2010; 161 (1): 19–27 https://www.ncbi.nlm.nih.gov/pubmed/20408856
2. Fakhfouri G, Rahimian R, Ghia JE, Khan WI, Dehpour AR. Impact of 5HT3 receptor antagonists on peripheral and central disease. Drug Discov. Today Jul 2012; 17 (13–14): 741-7
3. Khafipour E & Ghia JE. Mode of delivery and inflammatory disorders. J. Immunol. Clin. Res. September 2013, 1–1004
4. Gharedaghi MH, Seyedabadi M, Ghia JE, Dehpour AR, Rahimian R. The role of different serotonin receptor subtypes in seizure susceptibility. Exp. Brain. Res. Feb 2014; 232 (2): 347-67
https://www.ncbi.nlm.nih.gov/pubmed/24232860
5. Munyaka P*, Khafipour E & Ghia JE. External influence of early childhood establishment of gut microbiota and subsequent health implications. Front. Pediatr. Oct 2014; 2:109
https://www.ncbi.nlm.nih.gov/pubmed/25346925
6. Fakhfouri G, Mousavizadeh K, Mehr SE, Dehpour AR, Zirak MR, Ghia JE, Rahimian R. From Chemotherapy-induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 receptor Antagonists. Mol. Neurobiol. Dec 2015; 52 (3): 1670–1679
https://www.ncbi.nlm.nih.gov/pubmed/25377794
7. Eissa N* & Ghia JE. Immunomodulatory effect of ghrelin in the intestinal mucosa. Commissioned review, Neurogastroenterol. Motil., 2015 27 (11): 1519–1527
https://www.ncbi.nlm.nih.gov/pubmed/26503163
8. Beyder A#, de Lartigue G#, Ghia JE#, Hoffman JM#. XIVth Little Brain Big Brain:
next-generation enteric neuroscience. Nat Rev Gastroenterol Hepatol. 14 (3): 135–136, Jan 5, 2017. #Co-last author (Alphabetical order)
https://www.ncbi.nlm.nih.gov/pubmed/28053339
9. Seyedabadi M, Rahimian R*, Ghia JE. The role of alpha7 nicotinic acetylcholine receptors in inflammatory bowel disease: involvement of different cellular pathways. Expert Opin Ther Targets. Feb 2018; 22 (2):161–176.
https://www.ncbi.nlm.nih.gov/pubmed/29298542
10. Eissa N*, Hussein H*, Hendy GN, Bernstein CN, Ghia JE. Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation.Biochemical Pharmacology, April 2018; 152:315–326.
https://www.ncbi.nlm.nih.gov/pubmed/29656116
11. Banskota S, Ghia JE, Khan WI. Serotonin in the gut: Blessing or a curse. Biochimie Jun 2019; 161:56-64
https://www.ncbi.nlm.nih.gov/pubmed/29909048
EDUCATION – MEDICAL STUDENT TEXT BOOK – CHAPTER
1. Poitras P, Groleau V & Ghia JE. Chapitre l’estomac, L’appareil digestif 3 ed, 2019, Les Presses de l’Université de Montréal, 2020
https://www.pum.umontreal.ca/catalogue/lappareil_digestif_3e_ed