PUBLISHED MANUSCRIPTS (n=36)
* co-first authors, †corresponding author
-2004-
1. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F.† The effect of a chromogranin A-derived peptide (CgA4-16) in the writhing nociceptive response induced by acetic acid in rats. Life Sci. 2004; Aug 27, 75(15): 1787-99.
2. Ghia JE, Crenner F, Rohr S, Meyer C, Metz-Boutigue MH, Aunis D, Angel F.† A role for chromogranin A (4-16), a vasostatin-derived peptide, on human colonic motility. An in vitro study. Regul. Pept. 2004; Sep 15, 121(1-3): 31-9.
3. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F.† Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats. Regul. Pept. 2004; Jul 15, 119(3): 199-207.
-2005-
4. Ghia JE, Pradaud I, Crenner F, Metz-Boutigue MH, Aunis D, Angel F.† Effect of acetic acid or trypsin application on rat colonic motility in vitro and modulation by two synthetic fragments of chromogranin A. Regul. Pept. 2005; Jan 15, 124(1-3): 27-35.
-2006-
5. Ghia JE, Blennerhassett P, Verdu E, Ondiveeran KH, Collins SM.† The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006; Oct, 131(4): 1122-1130
-2007-
6. Verma-Gandhu M, Verdu E, Bercik P, Blennerhassett P, Al-Mutawaly N, Ghia JE, Collins SM.† Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse. Gut 2007; Mar, 56(3): 358-64
7. Ghia JE, Blennerhassett P, Collins SM.† Vagal integrity and experimental colitis. Am. J. Physiol. 2007; Sep, 293(3): G500-507
8. Ghia JE, Blennerhassett P, El-Sharkawy RT and Collins SM.† The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Am. J. Physiol. 2007; Oct, 293(4): G711-718
-2008-
9. Motomura Y, Ghia JE, El-Sharkawy RT, McLaughlin J, Grencis RK, Collins M, Khan WI.† Intestinal physiological changes and protective immunity to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 2008; Apr, 57(4): 475-81
10. Ghia JE, Galeazzi F, Ford DC, Hogaboam CM, Vallance BA and Collins SM.† Role of M-CSF dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am. J. Physiol. 2008; Mar, 294(3): G770-777
11. Ghia JE, Blennerhassett P, Collins SM.† Attenuation of colitis by tricyclic anti-depressant is mediated via the vagus nerve. J. Clin. Invest. 2008; June, 118(6): 2209-2218
-2009-
12. Ghia JE, Blennerhassett P, Deng Y, Verdu E, Khan WI and Collins SM.† Re-activation of inflammatory bowel disease in a mouse model of depression. Gastroenterology 2009; June, 136(7): 2280-2288
13. Ghia JE, Li N, Wang H, Collins M, Deng Y, El-Sharkawy RT, Cote F, Mallet J and Khan WI.† Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 2009; Nov, 137(5): 1649-1660
-2010-
14. Hasnain SZ, Wang H Ghia JE, Haq N, Deng Y* Grencis RK, Velcich A, Thornton DJ and Khan WI.† Mucin Gene Deficiency in Mice Impairs Host Resistance to Enteric Parasitic Infection. Gastroenterology 2010; May, 138(5): 1763-1771
-2011-
15. Ghia JE, Blennerhassett P, Khan WI, Collins SM.† The adoptive transfer of susceptibility to colitis by macrophages from mice with depression-like behavior. Inflammatory Bowel Disease 2011; Jul, 17(7): 1474-1489
16. Ghia JE*, Li N*, Wang H, Cote F, Suehiro Y, Mallet J & Khan WI.† Serotonin activates dendritic cell function in the context of gut inflammation. Am. J. Pathol. 2011; Feb, 178(2): 662-671
17. Rahimian R, Dehpour AR, Fakhfouri G, Khorramizadeh MR, Ghia JE, Seyedabadi M, Caldarelli A, Mousavizadeh K, Forouzandeh M, Mehr SE.† Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011; Oct, 1417: 1-8.
-2013-
18. Thanasupawat T, Hammje K, Adham I, Ghia JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T, Hombach-Klonisch S.† INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours. Oncol. Rep. 2013, Jan, 29(1):149-54
19. Kim JJ, Bridle BW, Ghia JE, Wang H, Manocha MM, Rengasamy P, Shajib MS*, Wan Y, Hedlund PB, Khan WI.† Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J. Immunol. 2013, May, 190(9): 4795-804
20. Park AJ, Collins J, Blennerhassett P*, Ghia JE, Verdu EF, Bercik P, Collins SM.† Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastrol. Motil. 2013, Sept, 25(9): 733-e575
21. Shajib MS, Wang H, Kim JJ, Sunjic I, Ghia JE, Denou E, Collins M, Denburg JA, Khan WI.† Interleukin 13 and serotonin: linking the immune and endocrine systems in intestinal inflammation, PLoS One 2013, Aug, 28;8(8), e72774
22. Rahimian R; Fakhfouri G; Samadi P; Mehr SE; Ghia JE; Genazzani AA; Dehpour AR; Mousavizadeh K; Lim D.† Tropisetron Attenuates Amyloid-Beta-Induced Inflammatory and Apoptotic Responses and cognitive disturbance in Rats. Eur. J. Clin. Invest. 2013, Oct, 43(10): 1039-1051
-2014-
23. JI H*, Rabbi MF*, Labis B*, Pavlov VA, Tracey KJ, Ghia JE.† Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis. Mucosal. Immunol. 2014, Mar, 7(2): 335-347 *Equal contribution
24. Nagy JI, Urena-Ramirez V, Ghia JE.† Functional deviations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons. FEBS Lett. 2014, Apr, 588 (8): 1480-1490
25. Rabbi MF; Labis B; Metz-Boutigue MH; Bernstein CN; Ghia JE.† Catestatin decreases macrophage function in two mouse models of experimental colitis. Biochem. Pharmacol. 2014, Jun, 89 (3): 386-398
26. Munyaka P, Rabbi MF, Pavlov VA, Tracey KJ, Khafipour E, Ghia JE.† Central muscarinic cholinergic activation alters dendritic cells function in experimental colitis. PLoS One 2014 Oct 8;9(10):e109272. doi: 10.1371/journal.pone.0109272. eCollection 2014
-2015-
27. Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford RJ, Collins A, Blumer R, Fullerton M, Kim J, Ghia JE, Hamza S, Morrison K, Dyck J, Schertzer J, Khan W, Yabut J, Steinberg G.† Inhibiting peripheral serotonin reduces obesity, non-alcoholic fatty liver disease and insulin resistance by promoting brown adipose tissue thermogenesis. Nat. Med. 2015 Feb; 21 (2): 166-72
28. Heydarpour P, Rahimian R, Fakhfouri G, Khoshkish S, Salehi-Sadaghiani M, Abbasi A, Wang H, Ahmad Reza Dehpour AR, Ghia JE.† Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway. Prog Neuropsychopharmacol. Biol. Psychiatry 2016 Jan; 64: 141-141
29. Munyaka PM, Eissa N, Bernstein CN, Khafipour E, Ghia JE.† Antepartum antibiotic treatment increases offspring’s susceptibility to experimental colitis: a role of the gut microbiota PLoS One 2015 Nov; 10 (11): e0142536
-2016-
30. Bernstein CN, Banerjee A, Targownik LE, Singh H, Ghia JE, Burchill C, Chateau D, Roos LL.† Caesarian section is not a risk factor for the development of IBD: A population based analysis. Clin. Gastroenterol. Hepatol. 2016 Jan; 14(1): 50-57
31. Munyaka PM*, Sepehri S, Ghia JE†, Khafipour E.† Carrageenan gum and adherent invasive Escherichia coli in a piglet model of inflammatory bowel disease: impact on intestinal mucosa-associated microbiota Front. Microbiol. 2016 Apr 5; 7; 462
32. Munyaka PM, Rabbi MF, Khafipour E, Ghia JE.† Acute dextran sulfate sodium (DSS)-induced colitis promotes gut microbial dysbiosis in mice. Journal Of Basic Microbiology 2016 Sep; 56 (9): 986-998
33. Eissa N, Hussein H, Rabbi MF, Khafipour A, Munyaka PM, Bernstein CN, Ghia JE.† Stability of Reference Genes for Messenger RNA Quantification by Real-Time PCR in Mouse Dextran Sodium Sulfate Experimental Colitis. PLoS One 2016 May 31; 11 (5):e0156289
-2017-
34. Bernstein CN, Burchill C, Targownik L, Singh H, Ghia JE, Roos LL.† Maternal antibiotic use or peripartum period is not associated with development of IBD in offspring: A population based analysis. Inflammatory Bowel Diseases, in press
35. Rabbi MF, Munyaka PM, Eissa N*, Khafipour E, Ghia JE.† Human catestatin induces gut microbiota dysbiosis in mouse. Frontiers Microbiology, in press
36. Eissa N*, Kermarrec L*, Hussein H, Bernstein CN, Ghia JE.† Appropriateness of reference genes for normalizing messenger RNA in mouse 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis using quantitative real time PCR. Original article, Nature Scientific Reports, in press
REVIEW PAPERS-PEER REVIEWED (n=8)
-2010-
1. Khan WI and Ghia JE.† Gut hormones: Emerging Role in Immune Activation and Inflammation. Clin. Exp. Immunol. 2010 Jul; 161(1): 19-27
-2012-
2. Fakhfouri G, Rahimian R, Ghia JE, Khan WI, Dehpour AR.† Impact of 5HT3 receptor antagonists on peripheral and central disease. Drug Discov. Today 2012 Jul; 17(13-14): 741-7
-2013-
3. Khafipour E & Ghia JE.† Mode of delivery and inflammatory disorders. J. Immunol. Clin. Res. September 2013, 1-1004
-2014-
4. Gharedaghi MH, Seyedabadi M, Ghia JE, Dehpour AR, Rahimian R.† The role of different serotonin receptor subtypes in seizure susceptibility. Exp. Brain. Res. 2014 Feb; 232(2): 347-67
5. Munyaka P*, Khafipour E & Ghia JE.† External influence of early childhood establishment of gut microbiota and subsequent health implications. Front. Pediatr. 2014 Oct; 2:109
-2015-
6. Fakhfouri G, Mousavizadeh K, Mehr SE, Dehpour AR, Zirak MR, Ghia JE, Rahimian R.† From Chemotherapy-induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 receptor Antagonists. Mol. Neurobiol. 2015 Dec; 52(3): 1670-1679
7. Eissa N* & Ghia JE.† Immunomodulatory effect of ghrelin in the intestinal mucosa. Commissioned review, Neurogastroenterol. Motil., 2015 27(11): 1519-1527
-2017-
8. Beyder A*, de Lartigue G*, Ghia JE*, Hoffman JM*. XIVth Little Brain Big Brain: next-generation enteric neuroscience. Nat Rev Gastroenterol Hepatol. 2017 Jan 5. *Co-last author (Alphabetical order)
* co-first authors, †corresponding author
-2004-
1. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F.† The effect of a chromogranin A-derived peptide (CgA4-16) in the writhing nociceptive response induced by acetic acid in rats. Life Sci. 2004; Aug 27, 75(15): 1787-99.
2. Ghia JE, Crenner F, Rohr S, Meyer C, Metz-Boutigue MH, Aunis D, Angel F.† A role for chromogranin A (4-16), a vasostatin-derived peptide, on human colonic motility. An in vitro study. Regul. Pept. 2004; Sep 15, 121(1-3): 31-9.
3. Ghia JE, Crenner F, Metz-Boutigue MH, Aunis D, Angel F.† Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats. Regul. Pept. 2004; Jul 15, 119(3): 199-207.
-2005-
4. Ghia JE, Pradaud I, Crenner F, Metz-Boutigue MH, Aunis D, Angel F.† Effect of acetic acid or trypsin application on rat colonic motility in vitro and modulation by two synthetic fragments of chromogranin A. Regul. Pept. 2005; Jan 15, 124(1-3): 27-35.
-2006-
5. Ghia JE, Blennerhassett P, Verdu E, Ondiveeran KH, Collins SM.† The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006; Oct, 131(4): 1122-1130
-2007-
6. Verma-Gandhu M, Verdu E, Bercik P, Blennerhassett P, Al-Mutawaly N, Ghia JE, Collins SM.† Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse. Gut 2007; Mar, 56(3): 358-64
7. Ghia JE, Blennerhassett P, Collins SM.† Vagal integrity and experimental colitis. Am. J. Physiol. 2007; Sep, 293(3): G500-507
8. Ghia JE, Blennerhassett P, El-Sharkawy RT and Collins SM.† The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Am. J. Physiol. 2007; Oct, 293(4): G711-718
-2008-
9. Motomura Y, Ghia JE, El-Sharkawy RT, McLaughlin J, Grencis RK, Collins M, Khan WI.† Intestinal physiological changes and protective immunity to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 2008; Apr, 57(4): 475-81
10. Ghia JE, Galeazzi F, Ford DC, Hogaboam CM, Vallance BA and Collins SM.† Role of M-CSF dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am. J. Physiol. 2008; Mar, 294(3): G770-777
11. Ghia JE, Blennerhassett P, Collins SM.† Attenuation of colitis by tricyclic anti-depressant is mediated via the vagus nerve. J. Clin. Invest. 2008; June, 118(6): 2209-2218
-2009-
12. Ghia JE, Blennerhassett P, Deng Y, Verdu E, Khan WI and Collins SM.† Re-activation of inflammatory bowel disease in a mouse model of depression. Gastroenterology 2009; June, 136(7): 2280-2288
13. Ghia JE, Li N, Wang H, Collins M, Deng Y, El-Sharkawy RT, Cote F, Mallet J and Khan WI.† Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 2009; Nov, 137(5): 1649-1660
-2010-
14. Hasnain SZ, Wang H Ghia JE, Haq N, Deng Y* Grencis RK, Velcich A, Thornton DJ and Khan WI.† Mucin Gene Deficiency in Mice Impairs Host Resistance to Enteric Parasitic Infection. Gastroenterology 2010; May, 138(5): 1763-1771
-2011-
15. Ghia JE, Blennerhassett P, Khan WI, Collins SM.† The adoptive transfer of susceptibility to colitis by macrophages from mice with depression-like behavior. Inflammatory Bowel Disease 2011; Jul, 17(7): 1474-1489
16. Ghia JE*, Li N*, Wang H, Cote F, Suehiro Y, Mallet J & Khan WI.† Serotonin activates dendritic cell function in the context of gut inflammation. Am. J. Pathol. 2011; Feb, 178(2): 662-671
17. Rahimian R, Dehpour AR, Fakhfouri G, Khorramizadeh MR, Ghia JE, Seyedabadi M, Caldarelli A, Mousavizadeh K, Forouzandeh M, Mehr SE.† Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011; Oct, 1417: 1-8.
-2013-
18. Thanasupawat T, Hammje K, Adham I, Ghia JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T, Hombach-Klonisch S.† INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours. Oncol. Rep. 2013, Jan, 29(1):149-54
19. Kim JJ, Bridle BW, Ghia JE, Wang H, Manocha MM, Rengasamy P, Shajib MS*, Wan Y, Hedlund PB, Khan WI.† Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J. Immunol. 2013, May, 190(9): 4795-804
20. Park AJ, Collins J, Blennerhassett P*, Ghia JE, Verdu EF, Bercik P, Collins SM.† Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastrol. Motil. 2013, Sept, 25(9): 733-e575
21. Shajib MS, Wang H, Kim JJ, Sunjic I, Ghia JE, Denou E, Collins M, Denburg JA, Khan WI.† Interleukin 13 and serotonin: linking the immune and endocrine systems in intestinal inflammation, PLoS One 2013, Aug, 28;8(8), e72774
22. Rahimian R; Fakhfouri G; Samadi P; Mehr SE; Ghia JE; Genazzani AA; Dehpour AR; Mousavizadeh K; Lim D.† Tropisetron Attenuates Amyloid-Beta-Induced Inflammatory and Apoptotic Responses and cognitive disturbance in Rats. Eur. J. Clin. Invest. 2013, Oct, 43(10): 1039-1051
-2014-
23. JI H*, Rabbi MF*, Labis B*, Pavlov VA, Tracey KJ, Ghia JE.† Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis. Mucosal. Immunol. 2014, Mar, 7(2): 335-347 *Equal contribution
24. Nagy JI, Urena-Ramirez V, Ghia JE.† Functional deviations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons. FEBS Lett. 2014, Apr, 588 (8): 1480-1490
25. Rabbi MF; Labis B; Metz-Boutigue MH; Bernstein CN; Ghia JE.† Catestatin decreases macrophage function in two mouse models of experimental colitis. Biochem. Pharmacol. 2014, Jun, 89 (3): 386-398
26. Munyaka P, Rabbi MF, Pavlov VA, Tracey KJ, Khafipour E, Ghia JE.† Central muscarinic cholinergic activation alters dendritic cells function in experimental colitis. PLoS One 2014 Oct 8;9(10):e109272. doi: 10.1371/journal.pone.0109272. eCollection 2014
-2015-
27. Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford RJ, Collins A, Blumer R, Fullerton M, Kim J, Ghia JE, Hamza S, Morrison K, Dyck J, Schertzer J, Khan W, Yabut J, Steinberg G.† Inhibiting peripheral serotonin reduces obesity, non-alcoholic fatty liver disease and insulin resistance by promoting brown adipose tissue thermogenesis. Nat. Med. 2015 Feb; 21 (2): 166-72
28. Heydarpour P, Rahimian R, Fakhfouri G, Khoshkish S, Salehi-Sadaghiani M, Abbasi A, Wang H, Ahmad Reza Dehpour AR, Ghia JE.† Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway. Prog Neuropsychopharmacol. Biol. Psychiatry 2016 Jan; 64: 141-141
29. Munyaka PM, Eissa N, Bernstein CN, Khafipour E, Ghia JE.† Antepartum antibiotic treatment increases offspring’s susceptibility to experimental colitis: a role of the gut microbiota PLoS One 2015 Nov; 10 (11): e0142536
-2016-
30. Bernstein CN, Banerjee A, Targownik LE, Singh H, Ghia JE, Burchill C, Chateau D, Roos LL.† Caesarian section is not a risk factor for the development of IBD: A population based analysis. Clin. Gastroenterol. Hepatol. 2016 Jan; 14(1): 50-57
31. Munyaka PM*, Sepehri S, Ghia JE†, Khafipour E.† Carrageenan gum and adherent invasive Escherichia coli in a piglet model of inflammatory bowel disease: impact on intestinal mucosa-associated microbiota Front. Microbiol. 2016 Apr 5; 7; 462
32. Munyaka PM, Rabbi MF, Khafipour E, Ghia JE.† Acute dextran sulfate sodium (DSS)-induced colitis promotes gut microbial dysbiosis in mice. Journal Of Basic Microbiology 2016 Sep; 56 (9): 986-998
33. Eissa N, Hussein H, Rabbi MF, Khafipour A, Munyaka PM, Bernstein CN, Ghia JE.† Stability of Reference Genes for Messenger RNA Quantification by Real-Time PCR in Mouse Dextran Sodium Sulfate Experimental Colitis. PLoS One 2016 May 31; 11 (5):e0156289
-2017-
34. Bernstein CN, Burchill C, Targownik L, Singh H, Ghia JE, Roos LL.† Maternal antibiotic use or peripartum period is not associated with development of IBD in offspring: A population based analysis. Inflammatory Bowel Diseases, in press
35. Rabbi MF, Munyaka PM, Eissa N*, Khafipour E, Ghia JE.† Human catestatin induces gut microbiota dysbiosis in mouse. Frontiers Microbiology, in press
36. Eissa N*, Kermarrec L*, Hussein H, Bernstein CN, Ghia JE.† Appropriateness of reference genes for normalizing messenger RNA in mouse 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis using quantitative real time PCR. Original article, Nature Scientific Reports, in press
REVIEW PAPERS-PEER REVIEWED (n=8)
-2010-
1. Khan WI and Ghia JE.† Gut hormones: Emerging Role in Immune Activation and Inflammation. Clin. Exp. Immunol. 2010 Jul; 161(1): 19-27
-2012-
2. Fakhfouri G, Rahimian R, Ghia JE, Khan WI, Dehpour AR.† Impact of 5HT3 receptor antagonists on peripheral and central disease. Drug Discov. Today 2012 Jul; 17(13-14): 741-7
-2013-
3. Khafipour E & Ghia JE.† Mode of delivery and inflammatory disorders. J. Immunol. Clin. Res. September 2013, 1-1004
-2014-
4. Gharedaghi MH, Seyedabadi M, Ghia JE, Dehpour AR, Rahimian R.† The role of different serotonin receptor subtypes in seizure susceptibility. Exp. Brain. Res. 2014 Feb; 232(2): 347-67
5. Munyaka P*, Khafipour E & Ghia JE.† External influence of early childhood establishment of gut microbiota and subsequent health implications. Front. Pediatr. 2014 Oct; 2:109
-2015-
6. Fakhfouri G, Mousavizadeh K, Mehr SE, Dehpour AR, Zirak MR, Ghia JE, Rahimian R.† From Chemotherapy-induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 receptor Antagonists. Mol. Neurobiol. 2015 Dec; 52(3): 1670-1679
7. Eissa N* & Ghia JE.† Immunomodulatory effect of ghrelin in the intestinal mucosa. Commissioned review, Neurogastroenterol. Motil., 2015 27(11): 1519-1527
-2017-
8. Beyder A*, de Lartigue G*, Ghia JE*, Hoffman JM*. XIVth Little Brain Big Brain: next-generation enteric neuroscience. Nat Rev Gastroenterol Hepatol. 2017 Jan 5. *Co-last author (Alphabetical order)